/ Welcome to HOPE

Disrupting Neurodegeneration with Cell-Based Precision

HOPE-Neuron Therapeutx is pioneering a non-stem-cell, device-enabled therapy to restore immune balance and deliver real immunometobolic hope for ALS patients and beyond.
/ What We Do

Where Science Meets HOPE

HOPE-Neuron Therapeutx is a neurobiology company developing SELanetx™, a novel therapeutic platform designed to treat ALS and related autoimmune neurodegenerative disorders. By harnessing mechanotransduction and controlled hyperoxia, we trigger a natural apoptotic process that reprograms the immune system—without drugs or stem cells.

Backed by published research, leading clinical partnerships, and a growing global IP portfolio, we aim to bring disruptive, scalable healing to patients with ALS, MS, Parkinson’s, and eventually Alzheimer’s.

Explore Our Platform

Device enhanced Hyperoxia Generated Apoptotic Activation

Whole blood Apoptotic Activation via Precision Cellular Control

Apoptosis Signals “Efferocytosis” and the M1-M2 Immune Cell-Shift

Sterile 30-minute Closed-Loop, 300~ml IV, Withdrawal & Re-Infusion

“It works”, p<0.008, M1-M2 Cell-Shift impacting disease, delivers HOPE

/ OUR SCIENCE

SELanetx™: Precision Apoptogenics

A cell-based (not stem cell) therapeutic platform engineered to reverse immune dysfunction.
Non-drug, sterile 30-minute IV treatment
Mechanotransduction-enhanced hyperoxia
Stimulates apoptotic cells (ACs) in withdrawn blood
Reinforces efferocytosis – switching chronic M1 "killer" cells to M2 "healer" cells
Closed-loop, point-of-care system requiring just ~300mL of blood
/ PRECLINICAL RESULTS

Proof of Concept:
From Treadmill to Clinic

In preclinical studies, ALS mice treated with SELanetx™ experienced significant improvements in motor function. While untreated mice fell off the treadmill, treated mice "ran, ran, ran" — correlating with a successful M1-to-M2 immune phenotype shift and improved quality of life. These promising results drive our clinical ambitions.
/ FUTURE INDICATIONS

Beyond ALS: A Treatment for Autoimmune-Neurodegenerative Diseases

The mechanism behind SELanetx™ is broadly applicable across neuroinflammatory diseases. Following ALS, we plan to extend validation and human IRB trials into:

Problem

Multiple Sclerosis (MS)

Problem

Parkinson’s Disease (PD)

Problem

Alzheimer’s Disease (AD)

By rebalancing the immune system through natural apoptotic pathways, we aim to transform the treatment of chronic neurodegeneration.

Learn More About Our Therapy